منابع مشابه
Prostaglandin E receptors and the kidney.
Prostaglandin E(2) is a major renal cyclooxygenase metabolite of arachidonate and interacts with four G protein-coupled E-prostanoid receptors designated EP(1), EP(2), EP(3), and EP(4). Through these receptors, PGE(2) modulates renal hemodynamics and salt and water excretion. The intrarenal distribution and function of EP receptors have been partially characterized, and each receptor has a dist...
متن کاملProstaglandin E and F receptors in the uterus
Prostaglandins (PGs) are necessary for normal female reproduction. PGs act via their respective receptors and execute various functions in their target tissues depending on which type of receptor being activated. PG receptors are G-protein coupled receptors mediating various vital processes in the uterus throughout the reproductive cycle and pregnancy. They are essential for the normal function...
متن کاملTargeting prostaglandin E EP receptors to inhibit metastasis.
It is well established that high cyclooxygenase-2 (COX-2) expression contributes to the aggressive behavior of breast and other malignancies. Due to concerns regarding the safety of long-term use of COX-2 inhibitors as well as a desire to seek more effective alternatives to prevent and treat metastatic disease, we tested the hypothesis that inhibition of downstream signaling by the COX-2 produc...
متن کاملCharacterization of murine vasopressor and vasodepressor prostaglandin E(2) receptors.
Four E-prostanoid (EP) receptors, designated EP(1), EP(2), EP(3), and EP(4), mediate the cellular effects of prostaglandin E(2) (PGE(2)). The present studies pharmacologically characterize the vasopressor and vasodepressor EP receptors in wild-type mice (EP(2)(+/+) mice) and mice with targeted disruption of the EP(2) receptor (EP(2)(-/-) mice). Mean arterial pressure (MAP) was measured via a ca...
متن کاملProstaglandin E2 inhibits eosinophil trafficking through E-prostanoid 2 receptors.
The accumulation of eosinophils in lung tissue is a hallmark of asthma, and it is believed that eosinophils play a crucial pathogenic role in allergic inflammation. Prostaglandin (PG) E(2) exerts anti-inflammatory and bronchoprotective mechanisms in asthma, but the underlying mechanisms have remained unclear. In this study we show that PGE(2) potently inhibits the chemotaxis of purified human e...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.r600038200